By Nikki A. Ford, John DiGiovanni, Stephen D. Hursting (auth.), Mikhail G. Kolonin (eds.)

ISBN-10: 1461476593

ISBN-13: 9781461476597

ISBN-10: 1461476607

ISBN-13: 9781461476603

Recent stories have proven that cells from adipose tissue are in a position to trafficking to tumors, therefore allowing paracrine motion of adipokines from in the tumor microenvironment. elevated tumor vascularization, immune approach suppression and direct results on malignant phone survival and proliferation were investigated as mechanisms regulated by way of adipokines. The objective of this publication is to debate facts pointing to the position of adipose tissue in melanoma and to dissect person mechanisms by which adipose tissue extra or restrict may perhaps effect melanoma progression.

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Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109:1292–8. 74. Kucerova L, Altanerova V, Matuskova M, Tyciakova S, Altaner C. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007;67: 6304–13. 75. Martin-Padura I, Gregato G, Marighetti P, Mancuso P, Calleri A, Corsini C, et al. The white adipose tissue used in lipotransfer procedures is a rich reservoir of CD34+ progenitors able to promote cancer progression.

J Natl Cancer Inst. 2005;97:1679–87. 105. Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011;365:1713–25. 106. Fujisawa T, Endo H, Tomimoto A, et al. Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut. 2008;57:1531–8. 107. Sugiyama M, Takahashi H, Hosono K, et al. Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol. 2009;34:339–44. 108. Kim AY, Lee YS, Kim KH, et al. Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation.

On this basis, the development of ER-negative breast cancer results from estrogen independence with growth promotion arising from the stimulatory activity of growth factors such as insulin [30], insulin-like growth factors, and some adipokines, notably leptin [31]. 5 Upper Versus Lower Body Obesity and Breast Cancer Risk The distribution of body fat, as opposed to general obesity, has also been related to the breast cancer risk. Typically, body fat locates to either the upper abdominal part of the body or to lower sites around the hips and thighs.

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Adipose Tissue and Cancer by Nikki A. Ford, John DiGiovanni, Stephen D. Hursting (auth.), Mikhail G. Kolonin (eds.)

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